序号

文献标题

影响因子

客户单位

吉玛产品

动物类型

注射方式

注射部位

1

Self-degradable “gemini-like” ionizable lipid￾mediated delivery of siRNA for   subcellular￾specific   gene therapy of hepatic diseases

14.6

沈阳药科大学

TNFa siRNA, DGAT2 siRNA，Cy5-siRNA

C57BL/6小鼠

尾静脉给药

尾部静脉血管

2

tRNA-Derived   Fragment tRF-22 Promotes Immunosuppression by Inhibiting HnRNPAB   Ubiquitination in Esophageal Squamous Cell Carcinoma

14.1

山东大学齐鲁医院

Antagomir（antagotRF-22）

小鼠

静脉注射

尾静脉全身输注

3

miRNA-loaded   biomimetic nanoparticles orchestrate gut microbe to ameliorate inflammatory   bowel disease

12.5

复旦大学

miRNA   mimics

小鼠

口服

灌胃

4

Dual   Strategies Based on Golgi Apparatus/Endoplasmic Reticulum Targeting and   Anchoring for High-Efficiency siRNA Delivery and Tumor RNAi Therapy

15.8

四川大学

siRNA

小鼠

静脉给药

尾静脉

5

Artesunate   Nanoplatform Targets the Serine–MAPK Axis in
    Cancer-Associated Fibroblasts to Reverse Photothermal
    Resistance in Triple-Negative Breast Cancer

27.4

复旦大学附属肿瘤医院

小干扰RNA

小鼠

皮下注射

瘤周

6

Restricting   intracellular Salmonella proliferation by coordinating p-TBK1 mediated   mitophagy and xenophagy

17.1

中国农业大学

小鼠体内siRNA

小鼠

腹腔注射

腹腔注射

7

Dysregulation   of CircZNF79(5) Modulates YBX1 Stability
    and Selective Autophagy to Drive Hepatocellular Carcinoma
    Progression

14.1

新乡医学院

siRNA，慢病毒，探针，过表达质粒，sh质粒

——

——

皮下注射

8

YY1   enhances HIF-1α stability in tumor-associated macrophages to suppress   anti-tumor immunity of prostate cancer in mice

15.7

东南大学附属中大医院

siRNAs   targeting YYl, HlF-la, and NUSAP1

C57小鼠

皮下注射

皮下瘤周围（后腿外侧）

9

GP73-dependent   regulation of exosome biogenesis promotes colorectal cancer liver metastasis

33.9

军事医学研究院生物工程研究所

siRNA   oligo

小鼠

静脉注射

尾静脉

10

Glioblastoma   cell derived exosomes as a potent vaccine platform targeting primary brain   cancers and brain metastases

16

河南大学

oligo

C57BL/6黑鼠

皮内注射

左脚皮内注射

11

Tumor   cell-derived engineered exosome enhances effective immunotherapy for   orthotopic glioblastoma and its recurrences

10.9

河南大学

oligo

C57BL/6黑鼠

皮内注射

左脚皮内注射

12

Macrophage   membrane-encapsulated miRNA nanodelivery system for the treatment of   hemophilic arthritis

10.5

苏州大学附属第一医院

Cy5-agomir

大鼠

关节注射

双膝关节

13

Tenascin-R   aggravates Aβ production in the perforant pathway by regulating Nav1.6   activity in APP/PS1 mice

11

大连医科大学

lentiviral vector: TG-shTnR（动物）；EGF-L mutationA
    - EGF-L mutationE等多个质粒（细胞）

小鼠

脑内

海马

14

Radiation‑sensitive   circRNA promotes intestinal regeneration

10.2

中国医学科学院放射医学研究所

RNA   FISH SA-Biotin System kit (F32202/50, GenePharma, Shanghai, China)，siRNA

小鼠

137Cs辐射源腹部照射

腹部

15

Serpina3c   protects against metabolic dysfunction-associated steatotic liver disease in   offspring induced by prenatal prednisone exposure

52.7

武汉大学基础医学院

AAV8-GP-1-Serpina3c-mus-227，
    AAV8-GP-1-SJ-NC，
    siRNA (Mouse-Serpina3c, Human-NR3C1, Human-HDAC3 and Control)，
    pcDNA3.1(+)-mouse-GR(/NR3C1)，
    pcDNA3.1(+)-NC，
    pGL4-basic，
    pGL4-mouse-Serpina3c-promoter，
    pRL-TK

C57小鼠

尾静脉注射

尾静脉